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Descrizione

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Autore: Yasui
Editore: Academic Press (Elsevier Group)
Data di Pubblicazione: 2016
ISBN: 9780128002261
Pagine: 444

Key Features

• Analyzes the effects of environmental stimuli on epigenetic states and correlates them with neuropsychiatric disease induction
• Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
• Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment

Description

Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addiction to obesity contributed by leading experts in their respective fields. The epigenetic aspects for each disorder are discussed, the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states are particularly relevant to disease.
Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders. Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.