The landmark text that has defined internal medicine for generations of clinicians and students - completely updated with a more streamlined, functional presentation Through six decades, no resource has matched the encyclopedic scope, esteemed scholarship, and scientific rigor of Harrison's Principles of Internal Medicine. Both an educational tool and a clinical reference, it remains one of the most widely read and universally respected textbooks in all of medical publishing and the pinnacle of current medical knowledge. The Nineteenth Edition of Harrison's features a new slimmer presentation, logically divided into two volumes. Volume 1 covers essential foundational-level material on the basic principles underlying optimal patient care and assessment of signs and symptoms. Volume 2 is devoted to specific diseases and the best evidence based approaches to their management. Capturing the countless advances and developments across the full span of medicine, this edition of Harrison's offers a complete update of all content related to pathophysiology and pathophysiology, clinical trials, evidence-based practice guidelines, current diagnostic methods, and established and new treatment methods. NEW chapters on important topics such as Men's Health, Fatigue, Management of Heart Failure, Infertility, and Contraception Increased number of clinical decision trees, radiographic examples, clinical images, tables and summary lists Presented in two volumes: Volume 1 is devoted to cardinal manifestations of disease and approach to differential diagnosis; Volume 2 covers specific diseases and disorders.